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Volume 4 Number 1 January 2018

Prognostic Value of Serum Amyloid A Protein in Egyptian Infants with Hypoxic Ischemic Encephalopathy (HIE), Two Centers Experience


Authors: Ezzat Kamel Amin ; Mohamed Abdelaziz El-Gamasy ; Nariman Fathi Omar ; Al-Shimaa M Hegaz ; Naglaa Ali Khalifa
Pages: 11-19
Abstract
Background: It is often difficult to predict which newborn with HIE will develop neurological sequlae so there is an urgent need for predictors for adverse neurological outcomes in these infants. Aim of Study: To evaluate the serum levels of serum amyloid A (SAA) protein in newborns with HIE during the first week of life and after 3 and 6 months of follow up to assess its correlation with degree of HIE neurological sequlee. Patients and Methods; This case-control study was conducted on 72 infants; group (1) included 36 full term  neonates diagnosed as HIE and group (2)included 36 age and sex matched, infants as a control group, Serum amyloid A by ELIZA technique was measured at post natal age of  1 and 7 days, CT scan was done in justified cases .with follow up at age of 3 and 6 months for neurological sequlee. Results: SAA protein level was elevated in the asphyxiated group in comparison to the control group at day 1 and day 7, SAA level was significantly correlated to the Sarnat scoring system of HIE. SAA level significantly differ on follow up of developmental milestone at age of 3 and 6 months. ROC curve for validity of SAA for severity of HIE at cut off point > 25μg/ml at day 1 and at cut off point > 20 μg/ml at day 7  of HIE diagnosis reported sensitivity 100% and specificity 100%  .Conclusion: SAA correlates with the severity of HIE and higher SAA expression is a prognostic marker for morbidity in these infants.


Relation between Quantity of Disinfectant and Antiseptics Used and Appearance of Intra-Hospital Infections in the Region of Eastern Macedonia


Authors: Biljana Gjorgjeska ; Andonela Koceva ; Ivana Iceva ; Dino Karpicarov
Pages: 1-10
Abstract
It is well known that the type and quantity of used disinfectant and the disinfection procedures is directly related to the effects of their use. The aim of this study was to review of the use of antiseptics and disinfectants in the region of Eastern Macedonia over five years period. The data were collected from hospitals in the region of eastern Macedonia (Strumica, Veles, Stip and Kavadarci). The results of microbiological testing conducted by the public health institutes in the cities were also collected and used knowing that the routine testing period for microbiological controls in hospitals was 15 days. The results indicated that the number of conditionally pathogenic bacteria is reduced starting from 2011. The reduction of the quantity of disinfectant used is also noted from 2011. The results obtained in all hospitals examined show similar situation in the region of eastern Macedonia. We will present the results obtained from Clinical Centre - Stip as the center of this region. The amount of disinfectants and antiseptics consumed comparing with the microbiological data indicates their rational utilization starting from 2011. Use of disinfectants according to the standardized procedures established by the IHI times allows current daily care. The knowledge about the current situation permits the staff to take proper precautions. It is pointed out the role of IHI times in the hospitals, as well as the role of hospital pharmacists.