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International Journal of Healthcare and Medical Sciences

Online ISSN: 2414-2999
Print ISSN: 2415-5233

Quarterly Published (4 Issues Per Year)

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Volume 11 Number 1 September 2025

Effect of an Aqueous Extract of Justicia Flava (Forsk) Vahl (Acanthaceae) in Subacute Administration on Some Lipid and Protein Blood Parameters and on Cardiac Tissue

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Authors: Kouamé Djè Kouamé Wenceslas ; N’Guessan Yao Firmin ; Piba Serge Cherry, et.al.
Pages: 22-28
DOI: doi.org/10.32861/ijhms.111.22.28
Abstract

Justicia flava (Forsk) Vahl is one of the many medicinal plants widely used in the daily lives of Ivorian and African populations. Rats were divided into seven groups of 10 animals, each consisting of five males and five females. A control group received distilled water orally at 10 mL/kg bw. Groups 2 to 5 received EAJf orally at doses of 125, 250, 500, and 1000 mg/kg bw, respectively. Groups 6 (distilled water at 10 mL/kg bw) and 7 (EAJf at 1000 mg/kg bw) were the satellite groups for this experiment. Oral administration of EAJf during the subacute toxicity study showed that the extract is nontoxic. Blood samples were collected at D0, D28 and a third sample was taken 14 days after D28 and the animals’ hearts were weighed and the relative weights were then determined. Approximately 3 mL of blood was collected in dry serum tubes for biochemical analysis using the Culter (RAYTO-RT 7600S; China). The method used for the histochemical test is the paraffin embedding technique. EAJf at doses of pc showed that the relative heart weight of rats did not undergo any significant variation compared to that of rats in the control group. Administration of EAJf did not cause any significant variation in serum levels of total protein (TP), albumin (ALB), triglycerides (Trigly) and total cholesterol (Chol T) compared to those of the control group during the entire period of the experiment. Regarding rat heart histology, no damage was observed at the end of the experiment. Finally, subacute oral administration of EAJf was nontoxic to cardiac tissue and some lipid parameters.

Classification of Autonomous Nervous Functions to Replace the Meridian System for Acupuncture/Moxibustion/Massage

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Authors: Zi-Jian Cai
Pages: 1-21
DOI: doi.org/10.32861/ijhms.111.1.21
Abstract

Introduction: It is revealed by biomedical studies that the autonomous nervous system mediates most clinical effects of acupuncture/moxibustion/massage. Whereas, it is advantageous for the classical meridian system to instruct acupuncture/moxibustion/massage by classifying the various acupoints into related meridians. Purpose: It was aimed to replace the meridian system with the classification of autonomous nervous functions for acupuncture/moxibustion/massage. Methods: It was searched the relevant papers on autonomous nervous system and acupuncture/moxibustion/massage, then classified and summarized. Results and Discussions: It is classified the autonomous nervous functions into: (a) Adjacent/feedback modulation, like local chronic pain, itch, inflammation, acupuncture, and so on; (b) Remote multi-point sensing coordination, including autonomous coordination to visual or acoustic attention, arousal, sleep, insomnia, yawn, remote analgesia/hiccup acupuncture, etc; (c) Dynamic coordination, either contraction or stretch, including cardiovascular coordination for arm/hand movement, and leg movement to change the intestine/urinary-bladder; (d) Thoracic-abdominal-back coordination, including the sympathetic/parasympathetic regulation therein, with addition of enteric nervous system, cardiorenal interactions, gut blood-pressure interactions, etc; (e) Emotional coordination onto sympathetic/parasympathetic system and related psychiatric diseases; (f) Environmental coordination, including temperature regulation, day/night circadian coordination, and so on. Consistently, with clinical effects and biomedical supports for acupuncture/moxibustion/massage, it is corresponded the respective acupuncture/moxibustion/massage of acupoints to the classification of autonomous nervous functions, while listed the common acupoints of clear clinical effects for demonstration. Conclusions: It recommends to use the classification of autonomous nervous functions to replace the meridian system in acupuncture/moxibustion/massage jointly for both diagnosis and treatment.