Volume 4 Number 10 October 2018

Features of Inflammatory Markers in Patients With Coronary Heart Disease

Authors: Alyavi A. L. ; Alyavi B. A. ; Tulyaganova D. K. ; Aliahunova M. Yu ; Sabirzhanova Z. T. ; Nuritdinova S. K. ; Uzokov J. K. ; Khan T. A. ; Radjabova D. I. ; Sayfiev N. Y.
Pages: 188-192
Aim: of the study was to conduct a comparative analysis of inflammatory markers in patients with coronary heart disease of stable and unstable flow. Methods: 78 patients aged 36 to 75 years were enrolled in this study (mean age 58.2±12.6 years). Laboratory and instrumental data were obtained and assessed. IL-6, TNF-α in blood plasma was carried out by the method of enzyme immunoassay on a solid-phase analyzer «Humareader Single». Statistical processing of the obtained results was carried out using vibrational statistics methods recommended for biomedical research on the IBM PC AT Pentium IV. Results: In patients with unstable angina (UA), the frequency of elevated levels of CRP, TNF-α, and leukocytes was statistically significantly higher than in the group with stable ischemic heart disease (P<0.05). The mean levels of these markers were statistically significantly higher in patients with UA compared with patients with stable form of coronary heart disease (CHD, P<0.05): CRP (4.3 ± 2.4 and 2.9 ± 2.3 mg / L, p <0.05, respectively), TNF-α (10.5 ± 2.5 and 7.7 ± 3.4 pg / ml, p <0.05) and leukocytes (9.2 ± 2.5 6.9 ± 2.3x109 / l, p <0.05). The level of interleukin-6 in patients with UA was higher in comparison with patients with stable angina (SA, 3.4 ± 1.7 and 2.9 ± 0.5 pg/ml), but the difference was statistically not significant (p> 0.05 ). There were no significant differences in the level of fibrinogen and ESR between patients with UA and SA. Conclusion: It was noted that the signs of inflammation are detected both in patients with unstable forms and in patients with stable form of CHD, but the degree of inflammation in patients with UA (level of TNF-α, CRP and leukocytes) is higher than in patients with stable ischemic heart disease.

Spatial Clustering of Dengue Fever: A Baseline Study in the City of Kolkata

Authors: Krishna Sankar Ganguly ; Krishnendra Sankar Ganguly ; Asis Kumar Chattopadhyay ; Ambar Dutta ; Tapan Kumar Mukherjee ; Debashis Biswas
Pages: 170-187
Dengue Fever, a major global Vector-Borne public health concern, is considered a major threat for mortality and morbidity of human-population. As no public-health vaccine is not still available, for prevention of the disease different Vector Control methods are still the prime means. The key to success lies on analysis of geo-climatic, socio-cultural, politico-legal and economic condition of the area, seasonal variation, as well as the spatial spread of the disease. Among different cities of India, Kolkata, an important Metropolis, has been subjected to this study, where the spatial spread of dengue has been found to have some important characteristics. The authors of the present work, who have been working on Vector Borne Diseases and have effectively forecasted models of Urban Malaria for Kolkata, have attempted a baseline study on Spatial Clustering of Dengue Fever in the same City, based on a large survey data, conducted by the Kolkata Municipal Corporation. In this pursuit, Moran scatter-plot, Hot-Spot Map and Heat Map using LISA Tools were derived for consecutive two years, so that the possible spatial effects on Dengue incidences can be derived after Spatial Analytic techniques. Disease Control methods can only be derived following the detailed Statistical Analysis of the Spatial Clustering data.