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Volume 11 Number 2 April 2025

Computation of the Antimicrobial Efficacy and Phytochemical Properties of Cannabis Sativa Powder against Some Clinical Isolates


Authors: OSENI BOLANLE AZEEZ ; ADEKOLA ABDULWASIU
Pages: 9-15
DOI: doi.org/10.32861/jbr.112.9.15
Abstract
The phytochemical makeup and antibacterial qualities of Cannabis sativa powder are examined in this study, underscoring the plant’s potential as a substitute therapy for bacterial infections, especially those caused by bacteria resistant to antibiotics.  Clinical isolates of Bacillus cereus, Staphylococcus aureus, Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, and Serratia marcescens were used to assess the antibacterial activity of Cannabis sativa.  With differing degrees of inhibition against the microorganisms, the results showed strong antibacterial efficacy. The highest activity was observed against Klebsiella pneumoniae and Pseudomonas aeruginosa, with zones of inhibition measuring up to 5 mm and 4 mm, respectively. The effectiveness of Cannabis sativa extracts in preventing bacterial growth, namely against Klebsiella pneumonia and Pseudomonas aeruginosa, was further validated by the Minimum Inhibitory Concentration (MIC) experiments. Because of the expanding worldwide problem of antibiotic resistance, this study emphasizes the potential of Cannabis sativa as a source of antibacterial drugs. Future studies should identify the precise chemicals causing these effects and investigate their modes of action, which could lead to the development of new antimicrobial therapies. Overall, this study underscores the need to revisit traditional medicinal plants like Cannabis sativa in the search for innovative solutions to contemporary health challenges.