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Volume 4 Number 10 October 2018

The Effects of Gene Polymorphisms in Interleukin-4 on the Susceptibility of Rheumatoid Arthritis in a Iraq Population

Authors: Ishraq Abdul Ameer Salih ; Rabab Omran
Pages: 76-79
DOI: doi.org/10.32861/jbr.410.76.79
Rheumatoid Arthritis (RA) has been the most disease that recorded high number in Iraqi population, Interleukin-4 (IL-4) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); which it is  role of IL-4  genetic polymorphisms in RA. Method: A total of 50 unrelated IRAQ patients with RA and 40 healthy Iraqi  volunteers with no family histories of any autoimmune diseases were recruited. The promoter IL-4-590 C/T   polymorphisms were genotyped gene polymorphism implemented used RFLP  technique. Result:The  results show The genotype distributions and allele frequencies of IL-4-590 C/T   polymorphisms in RA patients were significantly different from healthy Statistically significant differences were observed in genotypes for IL-4-590  .The frequencies of the T allele on the IL- 4-590  were significantly increased in RA patients. Conclusion. The IL-4-590   promoter polymorphisms may be associated with increased risk of RA and could be used as genetic marker for assessing the susceptibility and severity of RA in Iraqi.