Volume 4 Number 8 August 2018

The Approach of Parents to Fever of Children: A Survey Study

Authors: Kemal Pismisoglu ; H?seyin Dag ; Habip Gedik ; Ahmet Dogan ; Rohat ?ztepeli ; Vefik Arica
Pages: 155-157
Objective: The aim of this study was to evaluate the approach of parents to fever of children and related factors. Methods: In this survey study, A 26-question survey was conducted the parents whose children were under 15 years of age and admitted to the department of Emergency at Ministry of Health Okmeydanı Training and Research Hospital between November 2014 and April 2015 due to fever. The survey questions included the presence of a thermometer at home, their manner of taking temperature, mother’s knowledge level about fever, methods applied for reducing fever, antipyretic use and their concerns as well as the demographic characteristics. Results: In the study, 250 parents who were parents of 132 boys and 128 girls enrolled and the mean age of mothers, fathers and children who participated in the study were 25, 29.3 and 3.6 years, respectively. Most of the families (81.2 %) were nuclear family which consists of mother, father and children. It was recorded that 3.2% of parents with the score 0; 19.2% of parents with the score 10; and 86.4% of parents with the score 5 according to fever concern scale rated from 0 to 10. Conclusion: Parents should be informed correctly about fever in children to prevent fever phobia that causes an excessive number of unnecessary applications to the emergency department, high health care cost, and labor loss at hospitals by physicians and public informative publications.

KATP Channel Activation by Statins Decreases Intra-Ocular Pressure. Should We Explore These Channels as Therapeutic Targets in Glaucoma?

Authors: Devindra Sehra ; Sudhish Sehra ; Shiv Tej Sehra
Pages: 147-154
Introduction: This review discusses the molecular mechanisms responsible for the normalization of otherwise raised intraocular pressure (IOP) in patients of glaucoma when they are administered statin therapy. Material and Methods: Literature published between 1990 and 2016 on the pathophysiology of glaucoma and the action of statins has been reviewed. Data Synthesis: A decrease in resistance to aqueous humor flow through trabecular meshwork (TM) in the eye tissue results in lessening of the raised intraocular pressure. KATP channels have been discovered in the eye tissue recently. Activation of KATP channels facilitates the flow of aqueous humor through the TM. This presumption is strengthened by the action of statins. Statins activate these KATP channels and, thereby, facilitate the aqueous flow through TM leading to relief in IOP. Statins interfere in the cholesterol biosynthesis pathway leading to decreased cholesterol synthesis. However, a simultaneous decrease in the level of ubiquinone leads to activation of KATP channels. Further, accumulation of LC Acetyl CoAs also activates these KATP channels. Expert Opinion: Statins decrease the elevated intraocular pressure in glaucoma by activating KATP channels. KATP channels are recently discovered therapeutic targets which may be exploited in the treatment of glaucoma.