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Volume 10 Number 1 March 2025

Study of the Chemical Constituents of the Hydroethanolic Extract of the Leaves of Lippia Multiflora Moldenke (Verbenaceae)


Authors: Sibiri Ferdinand Sanou ; Amian Brise Benjamin Kassi ; Philatryho Atché ; Yaya Soro
Pages: 1-20
DOI: doi.org/10.32861/ajc.101.1.20
Abstract
Lippia multiflora is an aromatic plant used in traditional medicine for its extracts (volatile and non-volatile) rich in bioactive molecules. In Africa, the infusion or decoction of the leaves is used orally to treat bronchial conditions. The objective of this study is to identify the phytochemical compounds present in the leaves of L. multiflora. The dichloromethane fraction, resulting from the hydroalcoholic extract, was obtained by maceration of the crushed dried leaves in an ethanol/water mixture (70/30: v/v) followed by liquid-liquid fractionations. After the phytochemical screening, the level of total polyphenols, total flavonoids and tannins were evaluated by colorimetric assay. Structural elucidation was carried out by gas chromatography coupled with mass spectrometry (GC-MS). The phytochemical screening results showed the presence of polyphenols, flavonoids, tannins, alkaloids and terpenoids then the dosage provided the level of total polyphenols, total flavonoids and total tannins. Linalool, linalool oxide, palmitic acid and N-(2-mehtylphenyl)-3-hydroxybut-2-en amide were identified as abundant compounds with respective proportions of 42.1 %, 22.1 %, 10.9 % and 10.6 %. The results could justify the traditional use of the plant in the treatment of various diseases.